In this first clinical routine experience, abdominal PCCT achieved superior overall image quality versus conventional CT, with higher Likert scores for general image quality, lower perceived noise, and fewer artifacts.
Objective image quality was also better with PCCT, with significantly higher SNR in fat, muscle, and air, but this came at the cost of higher radiation exposure in the initial manufacturer-default protocol.
In an ex vivo phantom study, the higher PCCT dose was accompanied by more DNA double-strand break foci than conventional CT, highlighting the need for protocol optimization before routine abdominal PCCT can be considered dose-efficient.